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There are several matches for 'DNA damage-inducible protein'.
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1801 matches
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organism
protein
1)
Escherichia coli K12
dinD - Protein involved in DNA repair.
[a.k.a. b3645, AAC76669.2, DIND_ECOLI,
DNA damage-inducible protein
]
2)
Homo sapiens
HPF1 - Histone PARylation factor 1; Acts as a cofactor for serine ADP-ribosylation by conferring serine specificity on PARP1 and PARP2: interacts with PARP1 and PARP2 and is able to change amino acid specificity toward serine. Promotes histone serine ADP- ribosylation in response to
DNA
damage
, limiting
DNA
damage
-
induced
PARP1 hyper-automodification, and ensuring genome stability. Serine ADP-ribosylation of
proteins
constitutes the primary form of ADP-ribosylation of
proteins
in response to
DNA
damage
. HPF1 also promotes tyrosine ADP-ribosylation, probably by conferring tyrosine specificity [...]
[a.k.a. histone PARylation factor 1, hsa:54969, NM_017867.2]
3)
Homo sapiens
GADD45GIP1 - Growth arrest and
DNA
damage
-
inducible
proteins
-interacting
protein
1; Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45
proteins
but occurs also in the absence of GADD45
proteins
. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial
protein
synthesis; Belongs to the mitochondrion-specific ribosomal protei [...]
[a.k.a. Q9BSM6, R-HSA-5368286, PLINP]
4)
Homo sapiens
DDIT4 -
DNA
damage
-
inducible
transcript 4
protein
; Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and
DNA
damage
. Regulates p53/TP53-mediated apoptosis in response to
DNA
damage
via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell typ [...]
[a.k.a. uc001jsx.2, BAA91214.1, DDIT4_HUMAN]
5)
Homo sapiens
DDIAS -
DNA
damage
-
induced
apoptosis suppressor
protein
; May be an anti-apoptotic
protein
involved in
DNA
repair or cell survival.
[a.k.a. XM_011544836, C11orf82, ENSP00000435424]
6)
Homo sapiens
PRKCD -
Protein
kinase C delta type regulatory subunit; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic
protein
during
DNA
damage
-
induced
apoptosis, but acting as an anti- apoptotic
protein
during cytokine receptor-initiated cell death, is involved in tumor suppression as well as survival of several cancers, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses. Nega [...]
[a.k.a. R-HSA-388396, Protein kinase C delta type regulatory subunit, R-HSA-9006925]
7)
Homo sapiens
GADD45A - Growth arrest and
DNA
damage
-
inducible
protein
GADD45 alpha; In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity (By similarity). Might affect PCNA interaction with some CDK (cell division
protein
kinase) complexes; stimulates
DNA
excision repair in vitro and inhibits entry of cells into S phase; Belongs to the GADD45 family.
[a.k.a. GADD45, 1647, ENSG00000116717]
8)
Homo sapiens
GADD45B - Growth arrest and
DNA
damage
-
inducible
protein
GADD45 beta; Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK.
[a.k.a. HPA029816, Q6IX74, AK293087]
9)
Homo sapiens
GADD45G - Growth arrest and
DNA
damage
-
inducible
protein
GADD45 gamma; Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK; Belongs to the GADD45 family.
[a.k.a. growth arrest and DNA damage inducible gamma, ENST00000494726.1, AF079806]
10)
Homo sapiens
DDIT3 -
DNA
damage
-
inducible
transcript 3
protein
; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and
induces
cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding
protein
(C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]
[a.k.a. ENSP00000447503, CHOP, NM_004083]
11)
Homo sapiens
DDIT4L -
DNA
damage
-
inducible
transcript 4-like
protein
; Inhibits cell growth by regulating the TOR signaling pathway upstream of the TSC1-TSC2 complex and downstream of AKT1.
[a.k.a. ENSP00000427301, CAI46176.1, HPA050903]
12)
Homo sapiens
TOPORS - E3 ubiquitin-
protein
ligase Topors; Functions as an E3 ubiquitin-
protein
ligase and as an E3 SUMO1-
protein
ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated
proteins
. May be involved in
DNA
damage
-
induced
cell death through IKBKE sumoylation.
[a.k.a. RING-type E3 ubiquitin transferase Topors, RP31, AB045733]
13)
Homo sapiens
RRP1B - Ribosomal RNA processing
protein
1 homolog B; Positively regulates
DNA
damage
-
induced
apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1. Likely to play a role in ribosome biogenesis by targeting serine/threonine
protein
phosphatase PP1 to the nucleolus. Involved in regulation of mRNA splicing (By similarity). Inhibits SIPA1 GTPase activity (By similarity). Involved in regulating expression of extracellular matrix genes (By similarity). Associates with chromatin and may play a role in modulating chromatin structure.
[a.k.a. NM_015056, CCDS33577, ENSG00000160208]
14)
Homo sapiens
TRIM39 - E3 ubiquitin-
protein
ligase TRIM39; [Isoform 1]: E3 ubiquitin-
protein
ligase. May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly- ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic
protein
MOAP1. Regulates the G1/S transition of the cell cycle and
DNA
damage
-
induced
G2 arrest by stabilizing CDKN1A/p21. Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex- mediated CDKN1A/p21 ubiquitination and degradation.
[a.k.a. TRIM39-206, NP_001356451, ENSP00000394320]
15)
Homo sapiens
FOXN3 - Forkhead box
protein
N3; Acts as a transcriptional repressor. May be involved in
DNA
damage
-
inducible
cell cycle arrests (checkpoints).
[a.k.a. NP_001078940, AAB58252.1, hsa:1112]
16)
Homo sapiens
CXXC5 - CXXC-type zinc finger
protein
5; May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells (By similarity). Required for
DNA
damage
-
induced
ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis. Transcription factor. Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen). May repress COX4I2 transactivation
induced
by CHCHD2 and [...]
[a.k.a. NM_001317200.2, CCDS43370.1, NP_001304137.1]
17)
Mus musculus
Hpf1 - Histone PARylation factor 1; Acts as a cofactor for serine ADP-ribosylation by conferring serine specificity on PARP1 and PARP2: interacts with PARP1 and PARP2 and is able to change amino acid specificity toward serine. Promotes histone serine ADP-ribosylation in response to
DNA
damage
, limiting
DNA
damage
-
induced
PARP1 hyper-automodification, and ensuring genome stability. Serine ADP-ribosylation of
proteins
constitutes the primary form of ADP-ribosylation of
proteins
in response to
DNA
damage
. HPF1 also promotes tyrosine ADP-ribosylation, probably by conferring tyrosine specificity o [...]
[a.k.a. XM_006509512, NM_028299, ENSMUSP00000047235]
18)
Mus musculus
Gadd45gip1 - Growth arrest and
DNA
damage
-
inducible
proteins
-interacting
protein
1; Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45
proteins
but occurs also in the absence of GADD45
proteins
. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial
protein
synthesis.
[a.k.a. 102060, AK019570, AK003314]
19)
Mus musculus
Ddit4 -
DNA
damage
-
inducible
transcript 4
protein
; Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and
DNA
damage
. Regulates p53/TP53-mediated apoptosis in response to
DNA
damage
via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell typ [...]
[a.k.a. AAP13851.1, AAI32646.1, Q9D3F7]
20)
Mus musculus
Ddias -
DNA
damage
-
induced
apoptosis suppressor
protein
; May be an anti-apoptotic
protein
involved in
DNA
repair or cell survival.
[a.k.a. ENSMUST00000208356.1, E9QLR9, NP_001074464]
1801 matches
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